Alaskan Klee Kai are our hobby, our real jobs are as scientists in the biotech field. Scroll down for publications!

Although I do what I can with the time given as a mom, and hobby breeder, I also have to allow time for scientific journal publications and research. Sometimes I have to pull back from showing and the Alaskan Klee Kai community to attend to other things. However, we never stop loving and playing with our dogs every day, and eventually we start getting involved again.

I work with human, bacterial, and viral DNA & RNA.
My past research was in the study of human protein structure for drug discovery applications and disease research. I have also done a significant amount of work on cancer related genes, AD, SIDS, Asthma, breast cancer, cloning, and robotics for biochemistry & proteomics. Many of my past projects were funded by JCSG and GNF.
As of August 2007 I changed jobs and became a Senior Research Associate. I now work in a private group with 13 other scientist’s in the field of biowarfare defense.
We are presently funded by Darpa, SAIC, Northrop Grumman, and Homeland Security. I do hope for our company to go Public someday so we all put in long hours.

One thing I have learned in life, is the more that I learn the more that I learn I do not know. As a word of wisdom, worry about those that “know everything” ;)

All the best,

Aprilfawn

 

 

Here are some of the 30 scientific journal publications I am an author on:

(updates soon)

 

  

30. Journal of Bacteriology 2006 188: 8259-8271

Experimental and Computational Assessment of Conditionally Essential Genes in E.Coli

A. Joyce, J. Reed, A. White, R. Edwards, A. Osterman, T. Baba,  S. Lesely, B. Palsson, S. Agarwalla

 

29. Article Journal of Structural and Functional Genomics  

Issue:  Volume 6, Numbers 2-3

Date:  September 2005

Pages: 89 – 94

Methods and Results for Semi-automated Cloning Using Integrated Robotics

Heath E. Klock¹, Aprilfawn White¹, Eric Koesema¹ and Scott A. Lesley¹

 

28. Proteins: Structure, Function, & Bioinformatics 2008 Mar 6; : 18324683

Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold.

 

27. Proteins: Structure, Function, & Bioinformatics 2008 Feb 14; : 18275082

Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution.

 

26. Proteins: Structure, Function, & Bioinformatics 2008 Feb 7; : 18260100

Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution.

 

25. Proteins: Structure, Function, & Bioinformatics 2007 Jul 25; : 17654724

Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 A resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate.

 

24. Proteins: Structure, Function, & Bioinformatics 2007 Jul 24; : 17654547

Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.

 

23. Proteins: Structure, Function, & Bioinformatics 2007 Jul 24; : 17654545

Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.

 

22. Proteins: Structure, Function, & Bioinformatics 2007 Jul 16; : 17636569

Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 A resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases.

 

 21. Proteins: Structure, Function, & Bioinformatics 2007 Jun 1; : 17546672

Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 Å resolution (p NA)

 

20. Proteins: Structure, Function, & Bioinformatics 2007 Apr 19; : 17444523

Crystal structure of TM1030 from Thermotoga maritima at 2.3 Å resolution reveals molecular details of its transcription repressor function (p NA)

 

19. Proteins: Structure, Function, & Bioinformatics Vol 65: 527-537 2006

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 Å resolution (p NA)

 

18. Proteins: Structure, Function, & Bioinformatics Vol 65:771-776 2006

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site (p NA)

 

17. Proteins: Structure, Function, & Bioinformatics Vol 65:777-782 2006

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p (p NA)

 

16. Proteins: Structure, Function, & Bioinformatics Oct 06 Vol 65 Issue 1

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 Å resolution (p NA

 

15. Proteins: Structure, Function, & Bioinformatics Sept 06 Vol 64 Issue 4

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution (p NA)

  

14. Proteins: Structure, Function, & Bioinformatics August 2006 Vol 64 Issue 3

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 Å resolution (p 808-813

 

 

13. Proteins: Structure, Function, & Bioinformatics June 2006 Vol 63 Issue 4

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å resolution (p 1106-1111)

 

12. Proteins: Structure, Function, & Bioinformatics June 2006 Vol 63 Issue 4

Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold (p 1112-1118)

 

11. Proteins: Structure, Function, & Bioinformatics April 2006 Vol 63 Issue 1

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution (p NA)

 

10. Proteins: Structure, Function, & Bioinformatics Jan 2006 Vol 62 Issue 1

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold (p 292-296)

 

9. Proteins: Structure, Function, & Bioinformatics Dec 2005 61: 1132-1136

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 Å resolution reveals a new fold (p 1132-1136)

 

8. Proteins: Structure, Function, & Bioinformatics Nov 2005 61:669-673

Crystal structure Hsp33 chaperone (TM1394) from Thermatoga maritima at 2.20 Å  resolution( pNA)

 

7. Proteins: Structure, Function, & Bioinformatics Nov 2005 Vol 61 Issue 2

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold.

 

6.Proteins:Structure, Function, & Bioinformatics Nov 2005 Vol 61 Issue 2

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold.

 

5. Proteins:Structure, Function, & Bioinformatics Sept 2005 1;60(4):797-802.

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution

 

4. Proteins:Structure, Function, & Bioinformatics Jun 2005 1;59(4):869-74.

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold.

 

3. Proteins:Structure, Function, & Bioinformatics Mar 2005 1;58(4):971-5.

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor

 

2. Proteins:Structure, Function, & Bioinformatics Mar 2005 1;58(4):976-81.

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.

 

1. Proteins:Structure, Function, & Bioinformatics  Feb 2005 15;58(3):755-8.

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A res